ArticleThe journal of physical chemistry. B2025
Protein Recognition of Linear and Cyclic Peptides of Homologous Sequences Implicated in the Aggregation of α-Synuclein.
Article in The journal of physical chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
Various amino acid sequences have been suggested to play key roles in the aggregation of α-synuclein (α-syn), implicated in Parkinson's disease and other synucleinopathies. A drug development strategy is, therefore, the design of molecules that bind to these sequences in the monomer. The latter, either alone or coupled with antiaggregation groups, could preclude homogeneous and/or heterogeneous primary nucleation by either blocking protein-protein interactions or stabilizing the monomer in its solution and/or membrane-bound conformations, respectively. Here, using molecular dynamics simulations, we assessed the specificity of
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