ArticleJournal of cosmetic dermatology2025
Exploring the Rheology and Clinical Potential of Calcium Hydroxylapatite-Hyaluronic Acid Hybrids.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exploring the Rheology and Clinical Potential of Calcium Hydroxylapatite-Hyaluronic Acid Hybrids.Journal of cosmetic dermatology · 2025Article
- Modulating rheology and bioactivity in dermal fillers: the emerging role of platelet-rich plasma (PRP).Frontiers in medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundCombining calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) with hyaluronic acid (HA) products using Cohesive Polydensified Matrix (CPM) technology leverages the volumizing and hydrating effects of HA and draws upon the regenerative properties of CaHA-CMC, providing a potentially synergistic approach in aesthetic filling treatments. Despite this potential, the rheological and physical properties of these hybrid fillers remain unreported.
objectiveTo characterize the rheological properties of CaHA-CMC blended with various CPM-HA products and identify factors influencing their physical and clinical behavior.
methodsHybrid fillers were prepared by mixing CaHA-CMC with different CPM-HA products at varying ratios (1:1 to 1:4 syringe CaHA:syringe CPM). Rheological properties, including storage modulus (G'), loss modulus (G″), complex shear modulus (G*), tan delta (tan δ), and complex viscosity (η*), were measured using an oscillatory rheometer. Extrusion force, cohesivity, stability, and axial strain (ε
resultsThe rheological properties of the hybrid fillers varied with the type of HA, mixing ratio, and crosslinking degree. Higher HA concentrations increased G', G″, and η*, enhancing gel stiffness and resistance to deformation, while increased HA dilution and lower crosslinking favored spread and injectability. The addition of CaHA-CMC to CPM-HA products always increased the G' in a volume-dependent manner. These properties were closely correlated with the fillers' performance in different tissue planes.
conclusionsThe properties of CaHA-CMC and CPM-HA hybrids influence their injection behavior and clinical outcomes. Understanding these factors can guide filler selection and application techniques to maximize safety, efficacy, and patient satisfaction in aesthetic treatments.
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Registered trials
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