ArticleCase reports in psychiatry2025
Low-Dose Clozapine Reduces Aggression in Violent Substance Use Disorder Patients at a Secure Rehabilitation Center.
Article in Case reports in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Managing aggressive behaviors in patients with substance use disorders (SUDs), particularly when accompanied by comorbid psychiatric disorders, presents considerable challenges. Clozapine is an atypical antipsychotic known for its effectiveness in treatment-resistant schizophrenia with evidence in support of its ability to reduce violent and aggressive behaviors. This case report describes two patients who were treated with clozapine and showed reduction in violent behaviors, as well as improvement in addiction issues during their stay in a secure rehabilitation center. This observation suggests that clozapine may offer considerable benefits in managing aggression in SUD patients with co-occurring psychiatric illness and highlights the need for further research to assess its broader applicability in complex cases beyond treatment resistant schizophrenia.
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