Evidence map›Paper›PMID 41081274›Full record

ArticleStructural heart : the journal of the Heart Team2025

Role of Early Prothrombotic Evaluation in Device-Related Thrombus Risk Stratification After Left Atrial Appendage Closure.

Pedro Cepas-Guillén, Mathieu Robichaud, Gilles O Hara, Jean-Michel Paradis, Jean Champagne, Hugo Delarochelliere, Erwan Salaun, Pierre-Olivier Sirois, Melanie Coté, Josep Rodés-Cabau

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Article in Structural heart : the journal of the Heart Team, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pedro Cepas-GuillénCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Mathieu RobichaudCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Gilles O HaraCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Jean-Michel ParadisCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Jean ChampagneCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Hugo DelarochelliereCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Erwan SalaunCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Pierre-Olivier SiroisCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Melanie CotéCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.
Josep Rodés-CabauCardiology Department, Quebec Heart & Lung Institute, Laval University, Quebec City, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Left atrial appendage closure (LAAC) is increasingly used for stroke prevention in patients with non-valvular atrial fibrillation and contraindications to oral anticoagulation. The potential role of early prothrombotic status assessment in evaluating device-related thrombus (DRT) risk following LAAC remains unclear. Methods: The study included 147 patients undergoing LAAC with oral anticoagulation contraindication. Coagulation activation markers-prothrombin fragment 1 + 2 and thrombin antithrombin III-were measured at baseline and 7 days postprocedure. Based on the 50th percentile of delta (%) changes, patients were classified into low or high prothrombotic status. Specific delta % thresholds were assessed, which could serve as noninvasive cutoffs to rule out DRT. Results: A total of 53 patients (36.1%) were classified as having high prothrombotic status. DRT occurred in 9 patients (6.1%), with a significantly higher incidence in the high prothrombotic group (15.1 vs. 1.1%, Conclusions: Early evaluation of coagulation markers provides valuable insight into DRT risk after LAAC. The proposed thresholds demonstrate a high negative predictive value, effectively identifying patients at low risk for DRT and supporting their use as noninvasive tools to safely rule out DRT. These markers could enable early antithrombotic de-escalation and reduce the need for repeat imaging. Further studies are warranted.

Indexed as

Antithrombotic treatmentAtrial fibrillationDevice-related thrombusLeft atrial appendage closure

Identifiers

PMID41081274
PMCPMC12508827

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.