ArticleCirculation reports2025
Association Between Serum N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) Levels and Frailty in Community-Dwelling Old-Old Older Adults - SONIC Study.
Article in Circulation reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Heart failure (HF) and frailty are increasing among aging populations, but because data on the association between potential cardiac overload or asymptomatic HF, measured by the serum level of N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and frailty among community-dwelling old-old older adults (≥75 years) are limited, we examined this association. Methods and Results: A cross-sectional analysis was conducted using data from a longitudinal cohort study. Frailty was assessed using the Japanese version of the Cardiovascular Health Study (J-CHS) criteria. Association between log-transformed NT-proBNP levels and frailty were examined using multinomial logistic regression. The discriminative ability of NT-proBNP for frailty was assessed using receiver operating characteristic (ROC) curve analysis. A total of 588 participants (46.9% female, median age: 77 (76-86) years) were included. Log-transformed NT-proBNP was significantly associated with frailty compared to robust (OR 1.69; 95% CI 1.23-2.32; P=0.001), even after adjusting for potential confounding factors. NT-proBNP had modest discriminative ability for frailty (AUC 0.64; 95% CI 0.59-0.70; P<0.001), with an optimal cutoff of 94.5 pg/mL. Conclusions: Elevated serum NT-proBNP levels are independently associated with frailty onset in community-dwelling old-old older adults, driven by the interaction between potential cardiac overload or asymptomatic HF and frailty. Serum NT-proBNP may be a useful tool for identifying frailty associated with cardiac overload.
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