ArticleNeuroimage. Reports2025
Altered white matter connection from the locus coeruleus to the thalamus in Parkinson's disease.
Article in Neuroimage. Reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Is There a Relationship Between Movement and Sleep Disturbances in Essential Tremor?Brain sciences · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Parkinson's disease (PD) is the fastest growing neurodegenerative movement disorder. It is characterized by both motor and non-motor, including neuropsychiatric disturbances such as depression and anxiety. The locus coeruleus (LC), a small nucleus in the brainstem, plays a key role in these symptoms and has white matter connections to the thalamus. This study aims to investigate this LC-thalamic tract in PD patients using ultra-high-field diffusion-weighted imaging (DWI) and to examine its relationship with non-motor symptoms. Methods: 100 participants, including 69 early-stage PD and 31 healthy control (HC) participants were evaluated using several questionnaires and a 7T diffusion MRI scan. Tractography was performed to reconstruct the LC-thalamic white matter tract, and diffusion parameters (FA, MD, AD, RD) were analysed. Results: PD patients showed significantly higher mean diffusivity (MD) and axial diffusivity (AD) in the white matter tissue compared to HC, indicating reduced white matter integrity. Discussion: This study shows the feasibility to visualize the LC-thalamic tract with the use of 7T DWI data. The results provide evidence of the association between the integrity of the white matter tracts and early PD development, highlighting its potential as a target for therapeutic interventions. Further research is needed to elucidate the role of the LC and its white matter connections in the progression of PD and neuropsychiatric and other symptoms.
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Registered trials
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