ArticleQuantitative imaging in medicine and surgery2025
Automated intertumoral susceptibility signal extraction combined with quantitative enhanced T
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endometrial cancer (EC) incidence is increasing, with prognosis influenced by the tumor microenvironment. Hypoxia-inducible factor-1α (HIF-1α) promotes radioresistance, but traditional detection methods are often limited. Susceptibility-weighted imaging enables non-invasive quantitative assessment of tumor hypoxia. This study aims to investigate the efficacy of utilizing automated intertumoral susceptibility signal (ITSS) intensities extraction combined with multiple quantitative parameters derived from enhanced T Methods: A cohort of 219 patients diagnosed with EC through pathological examination were stratified into high and low expression groups based on their levels of HIF-1α expression and underwent preoperative pelvic 1.5-T magnetic resonance imaging (MRI) scans. Disparities in ITSS ratio, magnitude value, phase value, and R Results: The high HIF-1α expression group exhibited significantly higher values for the ITSS ratio (0.145±0.148 Conclusions: The automatic extraction of ITSS based on ESWAN sequence enables the quantitative evaluation of HIF-1α expression in EC.
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