ArticleQuantitative imaging in medicine and surgery2025
MR-based fat fraction changes in subcutaneous adipose tissue in people with obesity undergoing a weight loss intervention: results from the LION study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Myocardial fat fraction in Becker muscular dystrophy and women carrying pathogenicJournal of neuromuscular diseases · 2026Article
- Quantification of skeletal muscle density, mass and fat fraction using single-energy computed tomography.Journal of orthopaedic translation · 2026Article
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11 authors.
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Abstract
Background: Subcutaneous adipose tissue (SAT) plays a significant role in metabolic regulation. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) can non-invasively measure proton density fat fraction (PDFF), providing quantitative methods for monitoring adipose tissue composition changes during obesity treatment. However, the comparative reliability of MRI versus MRS for evaluating SAT PDFF changes during weight loss, and the differential responses of superficial versus deep SAT depots, remain unclear. This study aimed to compare MRI and MRS methods in evaluating SAT PDFF variations in people with obesity before and after weight loss, compare PDFF changes between superficial and deep SAT, and examine associations with standard anthropometric markers. Methods: A human intervention study was conducted on adults with obesity [body mass index (BMI) ≥30 kg/m Results: A short-term weight loss intervention significantly reduced SAT PDFF, as measured by MRI (r=0.41, P=0.01) and MRS (r=0.38, P=0.01). MRI and MRS measurements of SAT PDFF demonstrated strong agreement at baseline (r=0.67, P<0.01), after weight loss (r=0.81, P<0.01), and for changes in PDFF (r=0.75, P<0.01). A significant decrease in PDFF was observed in both superficial and deep SAT after weight loss (P<0.01), with a significant difference in PDFF between the two depots after weight loss (P<0.05). Weight loss correlated significantly with decreases in both deep SAT PDFF (r=0.34, P<0.01) and superficial SAT PDFF (r=0.48, P<0.05). Furthermore, PDFF reductions correlated significantly with decreases in BMI (r=0.44, P<0.01) and body fat percentage (r=0.59, P<0.01). Conclusions: Both MRI and MRS can reliably quantify PDFF in SAT of people with obesity undergoing weight loss interventions. Both deep and superficial SAT PDFF decrease after weight loss and SAT PDFF reduction is related to body fat changes after weight loss.
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