ArticleQuantitative imaging in medicine and surgery2025
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Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal cancer (CRC) is among the most prevalent malignant neoplasms within the digestive system. Perineural invasion (PNI) is a significant predictor of CRC prognosis, thus the crucial need to predict PNI status prior to surgical intervention. The aim of this study was to explore the efficacy of Methods: This study involved the retrospective collection of Results: According to univariate analysis, the PNI group and the non-PNI group differed statistically significantly in the metabolic tumor volume (MTV) 40% (P=0.027), the total lesion glycolysis (TLG) 40% (P=0.027), TLG60% (P=0.033), the coefficients of variation (CV) (P<0.001), the heterogeneity index (HF) (P=0.021), PAT grade (P=0.002), cN stage (P<0.001), and cM stage (P=0.016). The results of the multivariate logistic regression analysis identified the following variables as independent risk factors for predicting PNI: CV [odds ratio (OR) =3.128, 95% confidence interval (CI): 1.476-6.628, P=0.003], PAT grade (PAT grade 2: OR =12.016, 95% CI: 2.859-50.509, P<0.001; PAT grade 3: OR =22.417, 95% CI: 4.291-117.104, P<0.001), and cN stage (OR =4.769, 95% CI: 1.636-13.900, P=0.004). The ROC curve indicated an area under the curve (AUC) value of 0.893 (95% CI: 0.837-0.949) for the nomogram model. The internal validation concordance index (C-index) was found to be 0.861. Calibration curves and DCA demonstrated that the nomogram model exhibited both good accuracy and clinical utility. Conclusions:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.