ArticleQuantitative imaging in medicine and surgery2025
Evaluation of liver fibrosis staging in patients with chronic hepatitis via the gadolinium washout rate: a comparative study with magnetic resonance elastography and pathology.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- A Feasibility study of a two-step ADC-PSAD-GWR rule for stratifying prostate lesions prior to biopsy.BMC medical imaging · 2026Article
- Dual-phase T1-mapping (DHR-MAP) for non-invasive assessment of advanced liver fibrosis and moderate hepatitis: a single-center validation study.BMC gastroenterology · 2026Article
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Abstract
Background: Liver fibrosis, which affects over 200 million patients with chronic hepatitis across the world, is a critical prognostic determinant, and its accurate staging is necessary for guiding interventions. Although biopsy remains the gold standard, its invasiveness and sampling variability necessitate the development of reliable noninvasive alternatives. Magnetic resonance elastography (MRE) offers high diagnostic accuracy but is limited by cost and hardware requirements. Gadolinium-based agents [e.g., gadobenate dimeglumine (Gd-BOPTA)] enable hemodynamic quantification, yet no integrated metric combines washout and wash-in dynamics for fibrosis staging. This study aimed to develop and validate the gadolinium washout rate (GWR)-a novel model integrating multiphase T1 mapping washout (renal clearance) and wash-in (hepatocellular uptake) features-for precise, accessible liver fibrosis staging. Methods: This retrospective study enrolled 174 patients with chronic hepatitis. Liver T1 mapping [unenhanced, 5-minute delayed, and 120-minute hepatobiliary phase (HBP)] and biopsy were performed. GWR, the relative enhancement rate of the HBP and delayed phase in the T1 mode and MRE were compared via Pearson correlation, logistic regression, receiver operating characteristic analysis, and fivefold cross-validation. Results: GWR and MRE showed strong correlations with fibrosis stages (GWR: R=0.485-0.533; MRE: R=0.454-0.683; P<0.001). For ≥ F3 fibrosis, GWR, as compared to MRE, had a higher hazard ratio (37.32 Conclusions: GWR is superior to MRE in diagnosing advanced fibrosis (≥ F3), offering higher predictive values and clinical net benefit. It provides a cost-effective, noninvasive alternative to MRE.
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