ArticlePeerJ2025
Eyestalk transcriptome analysis reveals sexually dimorphic host-parasite interactions: divergent molecular strategies of
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The Chinese mitten crab ( Methods: Morphological analysis, serological testing, and eyestalk transcriptome analysis were conducted on male and female parasitized and non-parasitized crabs to investigate the molecular mechanisms by which Results: The study revealed that parasitized hosts of both sexes were significantly smaller than normal individuals and exhibited gonadal atrophy. Male hosts displayed feminization of secondary sexual characteristics, whereas females showed no significant alterations. Testosterone and ecdysterone levels decreased in male hosts, whereas estradiol levels declined in female hosts. Transcriptomic profiling revealed differentially expressed genes predominantly associated with metabolic processes, stimulus response, signal transduction, and reproduction. Thirteen key candidate genes related to parasite-induced suppression of host molting and growth, fourteen key candidate genes involved in male reproductive regulation, and ten candidate genes affecting female gonadal development were identified. Key genes involved in gonadal development-including
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