Evidence map›Paper›PMID 41081101›Full record

ArticlePeerJ2025

Evaluation of NEUROG1 methylation status in stool specimens in the advanced adenomas and colorectal cancer.

Lijin Zhang, Aiping Lin, Jie Lin, Juan Chen, Mengshi Chen, Xunbin Yu, Yijuan Wu, Tao Wang, Yan Lu, Zhaofen Ba and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lijin ZhangDepartment of Gastroenterology, the Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.
Aiping LinDepartment of Gastroenterology, the Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.
Jie LinDepartment of Pathology, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Juan ChenDepartment of Gastroenterology, the Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.
Mengshi ChenDepartment of Gastroenterology, the Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.
Xunbin YuDepartment of Pathology, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Yijuan WuDepartment of Pathology, Fujian Provincial Hospital, Fuzhou, Fujian, China.
Tao WangJiangsu Microdiag Biomedical Technology Co., LTD, Suzhou, Jiangsu, China.
Yan LuJiangsu Microdiag Biomedical Technology Co., LTD, Suzhou, Jiangsu, China.
Zhaofen BaJiangsu Microdiag Biomedical Technology Co., LTD, Suzhou, Jiangsu, China.
Xiaowei ChengJiangsu Microdiag Biomedical Technology Co., LTD, Suzhou, Jiangsu, China.
Tiantian ZhangJiangsu Microdiag Biomedical Technology Co., LTD, Suzhou, Jiangsu, China.
Minghong ChenDepartment of Gastroenterology, the Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To assess the status of NEUROG1 methylation in the advanced adenoma and colorectal cancer. Methods: The NEUROG1 methylation in tissue and stool samples from patients with colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA) were evaluated using methylation-specific quantitative polymerase chain reaction (PCR). Results: In tissue samples, the NEUROG1 methylation detection rates were 36% for CRC, 24% for NAA, and 88% for AA. In stool samples, the NEUROG1 methylation detection had a sensitivity of 63.46% for CRC with a positive predictive value (PPV) of 85.94%. The overall diagnostic specificity of the test for the NAA and the healthy control was 76.32%, with a negative predictive value (NPV) of 40.28%. Conclusion: NEUROG1 methylation detection can potentially be used in the CRC and AA screening.

Indexed as

AdenomaBasic Helix-Loop-Helix ProteinsColorectal NeoplasmsDNA MethylationFecesNerve Tissue ProteinsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedSensitivity and SpecificityBasic Helix-Loop-Helix ProteinsBiomarkers, TumorNerve Tissue ProteinsNEUROG1 protein, humanColorectal cancerDiagnosisDNA methylationNEUROG1Stool

Identifiers

PMID41081101
PMCPMC12514994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.