ArticleJournal of oral biology and craniofacial research
Evaluation of the role of age in MMP 9 and MMP 2 levels in pulpal blood of teeth with symptomatic irreversible pulpitis.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: To assess MMP 2 and MMP 9 levels in pulpal blood of human molar teeth with symptomatic irreversible pulpitis in 2 different age groups. Materials and methods: Patients of two age groups young [18-40] and old [>60] with symptomatic irreversible pulpitis in molars were included in this study. Teeth were isolated using a rubber dam. The rubber dam, clamp, and tooth were decontaminated using a cotton swab drenched in 1 % NaOCl solution. Access cavities were then prepared using a diamond-coated bur in a contrangle handpiece under water-cooling. Subsequently, the caries was excavated using a sterile round bur. Pulpal blood was collected from the pulp chamber by placing the blunt end of a sterile inverted 60 size paper point for 1 min. The paper point was transferred into a sterile microcentrifugation tube and frozen at -20 °C immediately until further processing. The levels of MMP-9 and MMP-2 in these samples were measured using commercially available specific enzyme-linked immunosorbent assay (ELISA) kits. Data was analysed using an independent t-test. Results: The mean pulpal blood levels of MMP-9 in patients above 60 years (220 ng/ml) were significantly lower than those aged 18-40 years (468 ng/ml) ([p value < 0.05]The mean pulpal blood levels of MMP-2 in patients above 60 years (134 ng/ml) were significantly lower than in those aged 18-40 years (153 ng/ml [p value < 0.05]. Conclusion: MMP-9 and MMP-2 levels in pulpal blood of cariously exposed teeth with irreversible pulpitis can vary with age.
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