ReviewJournal of oral biology and craniofacial research
Mechanical properties and biocompatibility of graphene-reinforced materials for crowns and bridges: A systematic review and meta-analysis with emphasis on ceramics.
Review in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: This systematic review and meta-analysis investigated the mechanical characteristics and biocompatibility of graphene-reinforced materials, especially ceramics for dental crowns and bridges. Its goal was to synthesize the available evidence and highlight areas needed for future research. Methods: A systematic search was conducted on PubMed, Web of Science, Science Direct, and Google Scholar, following the PRISMA guidelines. Eight in vitro studies were included which assessed biocompatibility and mechanical performance, such as flexural strength, compressive strength, and hardness. The QUIN tool was used to assess the risk of bias, and random-effects models were used for the meta-analysis. Results: Graphene reinforcement significantly improved mechanical properties, with flexural strength increasing by ∼100 MPa in some ceramic systems (SMD: 1.26, 95 % CI: -0.20, 2.72) and hardness showing significant enhancement (SMD: 1.69, 95 % CI: 0.45, 2.94). Graphene oxide (GO) demonstrated antibacterial efficacy (SMD: 2.37, 95 % CI: 1.77, 2.97). Biocompatibility results were promising but limited by limited reporting. Variability in graphene type, concentration, and processing methods influenced outcomes. Conclusion: Graphene-reinforced ceramics have superior mechanical characteristics and are potentially biocompatible, which solves some of the primary issues with existing dental materials. However, standardization of methodologies, long-term clinical validation, and optimization of graphene integration are essential for clinical translation.
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