Evidence map›Paper›PMID 41080977›Full record

ArticleJCEM case reports2025

Late Diagnosis of X-Linked Arginine Vasopressin Resistance Presenting With Flow Uropathy in Adulthood.

Vivek Jha, Rahul Gupta, Sanja Medenica, Mirjam Christ-Crain, Pinaki Dutta

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vivek JhaDepartment of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.ORCID https://orcid.org/0000-0001-7247-5492
Rahul GuptaAll India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh 462020, India.
Sanja MedenicaDepartment of Endocrinology, Internal Medicine Clinic, Clinical Centre of Montenegro, University of Montenegro, Podgorica 81000, Montenegro.
Mirjam Christ-CrainDepartment of Endocrinology, Diabetes and Metabolism, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
Pinaki DuttaDepartment of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.ORCID https://orcid.org/0000-0001-5415-1611

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital arginine vasopressin resistance (AVP-R) is a rare inherited disorder caused by renal unresponsiveness to arginine vasopressin (AVP), leading to persistent polyuria and polydipsia. We report a 19-year-old male individual with a long history of excessive thirst and urination who remained undiagnosed until adulthood. Despite normal growth and development, he was found to have bilateral hydronephrosis and underwent pyeloplasty at age 19. Postoperative fluid restriction resulted in life-threatening hypernatremia and seizures. Further evaluation revealed persistently low urine osmolality despite hypernatremia, elevated plasma copeptin, and no response to desmopressin or vasopressin, confirming AVP-R. Genetic testing identified a hemizygous arginine vasopressin receptor 2 (

Indexed as

arginine vasopressin resistancehemizygous AVPR2 mutationobstructive uropathythiazide diureticsX-linked mutation

Identifiers

PMID41080977
PMCPMC12511773

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.