Evidence map›Paper›PMID 41080962›Full record

ArticleFrontiers in medicine2025

Effect of remote ischemic postconditioning on hepatic ischemia-reperfusion injury in patients undergoing laparoscopic hepatectomy: a randomized double-blinded controlled trial.

Chao Yang, Lijun Yang, Mingwang Zeng, Yunyan Zhu, Chuanwu Zhang, Jing Chen, Yi Wang, Jinji Peng, Li-Feng Wang, Maolin Zhong and 2 more

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Chao YangFirst Clinical Medical College of Gannan Medical University, Ganzhou, China.
Lijun Yang *First Clinical Medical College of Gannan Medical University, Ganzhou, China.
Mingwang Zeng *Department of Anesthesia Surgery Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Yunyan Zhu *First Clinical Medical College of Gannan Medical University, Ganzhou, China.
Chuanwu ZhangFirst Clinical Medical College of Gannan Medical University, Ganzhou, China.
Jing Chen *Department of Anesthesia Surgery Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Yi Wang *First Clinical Medical College of Gannan Medical University, Ganzhou, China.
Jinji Peng *First Clinical Medical College of Gannan Medical University, Ganzhou, China.
Li-Feng WangDepartment of Anesthesia Surgery Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Maolin Zhong *Department of Anesthesia Surgery Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Haiyu Xie *Department of Anesthesia Surgery Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Weidong LiangDepartment of Anesthesia Surgery Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatic ischemia-reperfusion injury (HIRI) remains a major determinant of outcomes after hepatectomy with hepatic portal occlusion. Animal studies suggest that remote ischemic postconditioning (RIPostC) could alleviate HIRI, but its clinical value is unclear. This trial aimed to evaluate the efficacy of RIPostC in patients undergoing laparoscopic hepatectomy. Methods: In this randomized controlled trial, 83 patients were assigned to receive either RIPostC (4 cycles of 5 min ischemia/5 min reperfusion) or no intervention. The primary endpoints were postoperative liver function biochemical markers in the serum [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) levels] on postoperative days 1 and 2. The secondary outcomes included intraoperative variables and hospital stay. Results: Data from a total of 72 patients (36 per group) were analyzed. RIPostC did not significantly reduce ALT, AST or TBIL compared with control group (all Conclusion: This study represents one of the first randomized controlled clinical evaluations of RIPostC during laparoscopic hepatectomy. Contrary to experimental findings, a single RIPostC protocol did not improve early postoperative liver function.

Indexed as

hepatectomyischemia–reperfusion injurylaparoscopic surgeryliver functionremote ischemic postconditioning

Identifiers

PMID41080962
PMCPMC12511077

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