SynthesisFrontiers in medicine2025
Guide-based interventions aimed at reducing physical restraints in intensive care unit: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Physical restraint in the intensive care units: a narrative review of current practices and outcomes.Journal of intensive care · 2026Review
- The Ethical Tightrope of Physical and Environmental Restraint in ICU: A Balancing Act.Nursing in critical care · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Despite widespread advocacy and organizational support for reducing the utilization of physical restraint (PR) in clinical settings, its application remains prevalent on a global scale. This study aims to identify and evaluate guide-based, high-quality interventions that can be effectively integrated into clinical practice to substantially reduce PR utilization rates. Methods: A comprehensive search of relevant databases was covered all available records from their establishment through November 10, 2024, including PubMed, the Cochrane library, Web of Science, CINAHL, EMBASE, the Joanna Briggs Institute (JBI), China National Knowledge Infrastructure (CNKI), Wanfang Data, China Science and Technology Journal Database (VIP), and Chinese BioMedical Literature Service System (SinoMed). The search specifically targeted randomized controlled trials (RCTs) that focused on guide-based interventions designed to reduce the utilization of PR in the intensive care unit (ICU). Two independent researchers systematically reviewed the literature, with each investigator independently extracting relevant data and assessing the methodological quality of included studies using standardized criteria. The subsequent meta-analysis was conducted using Review Manager software version 5.2. Results: A total of 14 RCTs, involving 4,338 participants, were included in the analysis. The results indicated that guide-based interventions significantly reduced the PR rate (RR = 0.72, Conclusion: Guide-based interventions can effectively reduce the utilization of PR with patients in ICU. Employing a multidisciplinary team, adjusting patient assessment frequency by PR type and standardizing the PR assessment scale are possible to reduce the utilization of PR. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024623625, identifier: CRD42024623625.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.