ArticleFrontiers in medicine2025
Hemoglobin-to-red blood cell distribution width ratio: a new insight into cognitive protection for obese individuals.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Prognostic value of RDW and its derivatives in ICU patients with hypertensive chronic kidney disease.BMC cardiovascular disorders · 2026Article
- Clinical applications of blood cell ratios in veterinary hematology: From diagnosis to prognosis.Veterinary and animal science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Aging and obesity are recognized as risk factors for cognitive decline. Hemoglobin (Hb) reflects oxygen supply capacity, while red blood cell distribution width (RDW) reflects levels of inflammation and oxidative stress. The hemoglobin-to-red blood cell distribution width ratio (HRR), by integrating the core physiological functions of Hb and RDW, can more comprehensively reflect the common mechanisms affecting aging, obesity, and cognitive function. The objective of this research was to explore the link between the HRR and cognitive performance among the obese population. Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) and employed multiple regression analysis, smooth curve fitting, and subgroup analysis to investigate the relationship between HRR and cognitive function. Results: 1,055 obese individuals aged ≥60 years participated in the study. After adjusting for covariates, HRR was significantly positively correlated with DSST scores (β = 14.45; 95% CI, 7.55-21.35) and total cognitive Z-scores (β = 1.53; 95% CI, 0.40-2.67). HRR was significantly negatively correlated with low cognitive function as assessed by DSST (OR = 0.04; 95% CI, 0.01-0.23). Compared to individuals with lower education levels, those with higher educational backgrounds showed a more pronounced positive correlation between HRR and DSST scores. Conclusion: Maintaining a higher HRR may be an important strategy for protecting cognitive function in obese individuals aged ≥60 years.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.