ArticleJournal of diabetes and metabolic disorders2025
Feasibility and preliminary effects of high-intensity interval training vs. moderate-intensity continuous training on inflammatory and metabolic biomarkers in type 2 diabetes: a pilot randomized controlled trial.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparative effects of long- and short-interval aerobic high-intensity interval training on glycemic control among individuals with type 2 diabetes: a network meta-analysis.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Effects of high-intensity interval training and moderate-intensity continuous training on type 2 diabetes mellitus: a meta-analysis and systematic review.Frontiers in endocrinology · 2026Pooled it
- Effect of high-intensity interval training on aerobic capacity, physical fitness, and body composition in martial arts athletes: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Elevated plasma calprotectin, an inflammatory biomarker, is linked to higher cardiovascular risk in type 2 diabetes (T2DM), suggesting lifestyle interventions like exercise may help regulate it. This pilot study evaluated the feasibility of future full-scale trial for comparing the effect of high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) on calprotectin in T2DM patients without cardiovascular disease. Methods: This open-label, randomized controlled pilot trial was conducted from December 2018 to March 2019 at the Rajaie Cardiovascular Institute, Tehran, Iran. Participants over 18 years of age with T2DM, an HbA1c between 6.5% and 10%, a BMI between 24 and 35 kg/m Results: Out of 58 T2DM patients assessed for eligibility, 18 were recruited (9 females, 9 males; mean age: 52 ± 6.0 years; mean BMI: 28.7 ± 3.8 kg/m Conclusions: This study demonstrated efficient participant recruitment, complete retention, and safety, indicating that a full-scale trial is feasible. The reduction in calprotectin levels in the HIIT group supports further investigation in the full-scale trial. Trial registration: Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01713-6.
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