ArticleACS polymers Au2025
Multi-postpolymerization Functionalization of PLA Enabled by Sulfide Tetrazines as a Single End-Group Moiety.
Article in ACS polymers Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Exploring the Power of Metal-Free Click Transformations toward the Synthesis of Highly Functionalized Dendrimers for Applications in Drug Delivery.ACS applied materials & interfaces · 2025Article
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4 authors.
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Abstract
The synthesis of well-defined and multifunctional polymeric systems for drug delivery is a topic of intense research. However, a major limitation in the functionalization of these systems for nanomedical applications is the reliance on toxic catalysts or non-biocompatible strategies for polymer coupling and ligation, as well as the need for extensive purification steps when multiple functionalization reactions are performed. In this work, we introduce tetrazines containing both a methyl sulfide and hydroxyl functionality as the initiator for ring opening polymerization of l-lactide. We demonstrate that the obtained polymer can be successfully conjugated to mPEG-SH by chemoselective tetrazine-thiol exchange in a traceless manner. The byproduct, methanethiol, is easily eliminated during the course of the reaction, thus avoiding the use of a toxic catalyst. Additionally, the same end group allows for further functionalization via inverse electron demand Diels-Alder chemistry using
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