Exploiting Machine Learning and Automated Synthesis in Continuous Flow for Process Optimization of the Organocatalyzed Ring-Opening Polymerization of l‑Lactide.

The ring-opening polymerization (ROP) of lactide is a well-established route for the synthesis of polylactide (PLA), a degradable and biobased polymer with applications in biomedical materials, packaging, and additive manufacturing. However, optimizing reaction conditions for efficient PLA synthesis remains challenging, with its production currently dwarfed by traditional petrochemical derived commodity polymers. In this work, we employ a continuous flow reactor to systematically explore a reaction space defined by catalyst concentration, residence time, and initiator concentration for the organocatalyzed ROP of l-lactide performed at room temperature, using 1,8-diaza-bicyclo​[5.4.0]​undec-7-ene (DBU) as catalyst, benzyl alcohol as initiator and dichloromethane as solvent. Through high-throughput experimentation coupled with online characterization, a robust data set was generated and processed with a Kernel-Based Regularized Least Squares (KRLS) model to capture system kinetics and the dependencies between initial conditions and polymer characteristics. Multiobjective Pareto optimization was subsequently used to identify conditions that maximize polymer production rate, and these conditions were experimentally validated to confirm the model accurately predicts optimal reaction conditions. Pareto-optimized parameters yield a high conversion and well-controlled PLA with low dispersities. This study highlights the advantages of continuous flow polymerization for precise control over reaction kinetics and demonstrates the potential of machine-learning-assisted optimization for efficient and scalable PLA-based materials' exploration.