ArticleFrontiers in public health2025
Spatiotemporal inequality and financial toxicity of leukemia in post-poverty China: a national analysis of 832 counties (2019-2024).
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- The Evolving Burden of Stroke in China's 832 Poverty-Alleviated Counties (2019-2024): Nationwide Spatiotemporal Analysis.JMIR public health and surveillance · 2026Article
- Temporal-spatial distribution characteristics and associated socioeconomic factors of medical expenditures for rural patients with chronic kidney disease in Fujian Province, Southeast China.International journal of health geographics · 2026Article
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Abstract
Background: Leukemia remains a critical public health challenge in China's post-poverty regions, where high treatment costs perpetuate the "disease-poverty" trap. Despite nationwide efforts to improve healthcare access, the evolving spatiotemporal dynamics and economic burden of leukemia in these regions remain understudied. Methods: Using population-based data from China's Health Poverty Alleviation Platform (2019-2024), we analyzed 97,472 leukemia cases across 832 poverty-alleviated counties. Age/sex-standardized incidence and mortality rates were calculated using 2020 census data. Spatiotemporal trends were evaluated via Joinpoint regression, and spatial clustering was mapped through global/local Moran's I and Getis-Ord Gi* analyses. The economic burden was assessed by Out-Of-Pocket (OOP) payment ratios and costs. Results: Longitudinal analysis of 97,472 leukemia cases across 832 Chinese poverty-alleviated counties (2019-2024) revealed: (1) Significant reductions in age-standardized incidence (AAPC = -59.4%, Conclusion: While China's poverty alleviation policies effectively reduced the leukemia burden, persistent regional disparities and financial toxicity demand targeted interventions. The westward hotspot migration post-2022 marks a diagnostic catch-up in resource-limited regions. Crucially, elevated male/youth incidence necessitates targeted screening in emerging clusters, while diverging financial toxicity demands region-specific solutions: for Eastern China's catastrophic OOP ratios (39.7%), reform must prioritize novel-therapy reimbursement; Central China's cost-clustering urges cross-provincial care networks to offset abandonment risks.
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