A review of pharmaceutical and personal care products and atopic dermatitis based on epidemiological and basic research findings.

Shushu Xie, Yan Jiang, Zhiqin Hu, Zhishan Ding, Jie Yu, Xiaoqing Ye

Abstract readReview

In one paragraph

Review in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shushu XieSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.

Yan JiangSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.

Zhiqin HuSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.

Zhishan DingSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.

Jie YuPuer Kunhong Biotechnology Company, Pu'er, China.

Xiaoqing YeSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmaceutical and personal care products (PPCPs) are emerging pollutants that have been found to be related to allergic diseases. Currently, a large amount of research focused on the association between PPCPs and atopic dermatitis (AD), but there has been no evaluation of existing evidence on this topic. Here, we reviewed epidemiological and toxicological studies from 2014 to 2024, with a focus on common PPCPs such as antibiotics, phthalates, p-hydroxybenzoic acid, etc. We found that most PPCPs are positively correlated with the onset of AD, with particular attention paid to exposure during pregnancy and infancy. This reminds AD patients to be cautious when taking medication and choosing nursing products. Animal studies have shown that the pathogenesis of PPCPs may be mediated by dysbiosis, immune imbalance and oxidative stress. Despite inconsistent results in existing research, PPCPs are confirmed to be unfavorable drivers of AD occurrence and progression. Clarifying their potential link with AD is critical for informing subsequent policy and regulatory decisions.

Indexed as

CosmeticsDermatitis, AtopicFemaleHumansParabensPregnancyCosmeticsParabensatopic dermatitisemerging contaminantshealth hazardsimmunotoxicitypharmaceutical and personal care productsrisk factors

Identifiers

PMID41080860

DOI10.3389/fpubh.2025.1642873

PMCPMC12507775

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.