Evidence map›Paper›PMID 41080731›Full record

ReviewMaterials today. Bio2025

Recent progress of 3D printed responsive scaffolds for bone repair: A review.

Yuxi Bai, Nannan Wu, Xinyu Li, Zhiwei Liu, Kun Li, Tifeng Jiao, Fei Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuxi BaiDepartment of Orthopedics, The First Hospital of Qinhuangdao, Qinhuangdao, 06600, China.
Nannan WuState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China.
Xinyu LiState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China.
Zhiwei LiuState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China.
Kun LiState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China.
Tifeng JiaoState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China.
Fei LiuDepartment of Orthopedics, The First Hospital of Qinhuangdao, Qinhuangdao, 06600, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects are complex in etiology, extensive in scope, and associated with local microenvironmental disruption, leading to issues such as donor site complications, poor biocompatibility, and inadequate functional recovery with traditional treatment methods (e.g., autologous bone transplantation, metal implants). Bone repair scaffolds have garnered widespread attention due to their excellent biomimetic properties and high repair efficiency. With the advantages of personalization, high-precision manufacturing and complex structure forming, 3D printing technology has shown great potential for application in the field of bone restoration. In contrast to conventional bone scaffolds, responsive scaffolds emulate the dynamic environment of the natural extracellular matrix, which can produce controlled effects in responding to stimuli, hence promoting cell multiplication and differentiation and bone regeneration. This review introduces the study of human bone structure and defects, summarizes the 3D printing technologies of preparing bone scaffolds, concludes the characteristics and applicability of different 3D printing technologies, then the applications of light, piezoelectric, temperature, immune, magnetic, and enzyme-responsive scaffolds in the field of bone repair are summarized according to the types of responses of bone scaffolds to various types of stimuli in the human body, and finally the problems faced by responsive scaffolds in the process of clinical translation are pointed out.

Indexed as

3D printingBone repairMultifunctional materialsResponsive scaffold

Identifiers

PMID41080731
PMCPMC12510199

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.