ArticleMaterials today. Bio2025
A novel folate receptor-targeted curcumin nano-delivery system: A dual therapeutic strategy for precise inhibition of MRCKβ to suppress ovarian cancer proliferation and immune escape.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- In situ sol-gel-sol transformation formed by sodium alginate realizes folic acid-modified chitosan nanoparticles to deliver hops β-acids for colorectal cancer therapy.Journal of nanobiotechnology · 2026Article
- The Potential Alleviating Property Against NAFLD byFood science & nutrition · 2026Article
- Preparation and Antitumor Activity Evaluation of Folic Acid-Modified Phospholipid-Gambogic Acid Nanocrystals.Pharmaceutics · 2026Article
- Synthesis and antibacterial properties of magnesium-based curcumin self-assembled material.Current research in food science · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Curcumin is a natural polyphenolic compound extracted from the rhizomes of Curcuma longa, exhibiting diverse biological activities, including anti-inflammatory, antioxidant, antitumor, antibacterial, antiviral, and neuroprotective effects. However, its clinical application is severely limited by poor oral absorption and low bioavailability. To address these challenges, this study synthesized a novel folate-targeted curcumin-loaded material-CU-FRα/PEG-2-CHO. This delivery system significantly enhances tumor cell uptake efficiency through folate receptor (FRα)-mediated active targeting (FRα denotes the folate receptor alpha subtype). Additionally, polyethylene glycol (PEG) modification and aldehyde (-CHO) functionalization further improve its water solubility and stability. Experimental results demonstrate that this material not only substantially increases curcumin's absorption rate and bioavailability but also enhances its antitumor activity via targeted delivery mechanisms. This study developed a new type (significantly improving various performances) folate receptor-targeted curcumin nano-delivery system (CU-FRα/PEG-2-CHO) and systematically compared the antitumor effects of two curcumin nanomaterials (CU-FRα/PEG-1-CHO and CU-FRα/PEG-2-CHO), demonstrating that CU-FRα/PEG-2-CHO significantly inhibited the growth of A2780 and HO8910PM ovarian cancer cell lines. After targeting tumor cells, CU-FRα/PEG-2-CHO released curcumin, which was mechanistically shown to specifically target Cdc42-binding kinase β (MRCKβ, IC
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