ReviewRSC advances2025
Overcoming colorectal cancer and cancer stem cell resistance with photodynamic therapy: new frontiers in oncology.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Shedding light on the cancer cell death mechanism in photodynamic therapy.Apoptosis : an international journal on programmed cell death · 2026Review
- Calcium hydroxide nanoparticles-induced oxidative stress and mitochondrial impairment drive genomic instability and programmed cell death in colorectal cancer cells.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is a major global health issue characterized by abnormal cell growth leading to high morbidity and mortality rates. While conventional treatments like chemotherapy and surgery exist, they often fall short due to severe side effects and the emergence of treatment resistance, particularly from cancer stem cells (CSCs). These CSCs contribute to tumor initiation, progression, and recurrence, posing challenges for effective management. Photodynamic therapy (PDT) offers a promising alternative, leveraging light-activated photosensitizers (PSs) to selectively target and destroy tumor cells while minimizing damage to healthy tissue. Recent advancements in PDT, including the use of nanoparticles (NPs) and novel PSs, enhance its efficacy against CRC and CSCs. Preclinical studies have demonstrated PDT ability to induce apoptosis and inhibit tumor growth in various models, highlighting its potential as a therapeutic strategy. Additionally, combining PDT with immune checkpoint inhibitors may further improve treatment outcomes by activating robust immune responses. This review discusses the mechanisms of resistance in CRC, the role of CSCs, and the evolving landscape of PDT, emphasizing the need for continued research to optimize combination therapies for enhanced efficacy against colorectal cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.