ArticleTobacco induced diseases2025
Role of OAF and smoking initiation in COPD risk: Insights from Mendelian randomization.
Article in Tobacco induced diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Narrative Review of the Correlation Between Comorbidity and Acute Exacerbation of COPD Patients.International journal of chronic obstructive pulmonary disease · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChronic Obstructive Pulmonary Disease (COPD) is a complex condition influenced by both genetic and environmental factors. This study aims to identify potential biomarkers and explore the associations between specific maker genes, smoking initiation, and COPD.
methodsWe used Mendelian randomization (MR) with inverse variance weighting (IVW) to identify significant associations (p<0.05). Genetic instruments for smoking initiation (Genome-Wide Association Study [GWAS]: ieu-b-4877) and Out at First (OAF) (cis-expression Quantitative Trait Locus [eQTL] GWAS) were selected based on single nucleotide polymorphisms (SNPs) with p<5×10
resultsWe identified OAF as a key genetic marker associated with COPD risk, with the eQTL analysis yielding an odds ratio (OR) of 1.09 (95% CI: 1.02-1.17, p=0.01). The IVW analysis for smoking initiation-COPD indicated an OR of 1.89 (95% CI: 1.69-2.11, p<0.001). Mediation analysis revealed that the immune cell phenotype CD14- CD16- absolute count (AC) (GCST90001581) accounted for 30.16% and 4.27% of the mediation in the OAF-COPD and smoking initiation-COPD associations, respectively.
conclusionsThe MR results suggest that OAF may be a genetic risk factor for COPD, with immune cell phenotypes, particularly CD14-CD16-AC, potentially playing a mediating role in COPD development. Smoking initiation is also positively correlated with COPD, playing an important role in its pathogenesis.
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