Evidence map›Paper›PMID 41080608›Full record

ArticleFrontiers in immunology2025

GSTP1 improves CAR-T cell proliferation and cytotoxicity to combat lymphoma.

Guangsong Xu, Jiani Wang, Yuliang Qu, Jing Ning, Yanting Zhang, Guangxian Xu, Yunxia Shi, Ying Li, Le Guo, Xuebo Han and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guangsong Xu *College of Laboratory Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Jiani Wang *College of Laboratory Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Yuliang Qu *College of Laboratory Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Jing NingHematology Department, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Yanting ZhangGastroenterology Department, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Guangxian XuMedical Technology College, Guangdong Medical University, Dongguan, Guangdong, China.
Yunxia ShiCollege of Laboratory Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Ying LiCollege of Laboratory Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Le GuoKey Laboratory of Clinical Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Xuebo HanCollege of Laboratory Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
Hongxia WangCollege of Laboratory Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The exhaustion of chimeric antigen receptor T cells (CAR-T) hampers the efficacy of CAR-T cell therapy. Persistent antigen stimulation in T cells results in a surge of intracellular reactive oxygen species (ROS). ROS, as mitochondrial metabolites, alter the integrity of the mitochondrial membrane and promote T-cell exhaustion. Glutathione Methods: The correlations between GSTP1 and genes related to T-cell exhaustion were analyzed using the TIMER database. Peripheral blood mononuclear cells (PBMCs) were collected from patients with hematologic malignancies ( Results: GSTP1 expression was downregulated when BLIMP1 and PD-1 were upregulated in PBMCs of cancer patients and in the Conclusion: BLIMP1 directly suppressed GSTP1 transcription, whereas GSTP1 overexpression enhanced the antitumor capacity of CAR-T cells and maintained redox homeostasis, providing a novel therapeutic strategy to improve CAR-T cell immunotherapy.

Indexed as

Cytotoxicity, ImmunologicGlutathione S-Transferase piImmunotherapy, AdoptiveLymphomaReceptors, Chimeric AntigenT-LymphocytesAnimalsCell Line, TumorCell ProliferationFemaleHumansLymphocyte ActivationMaleMicePositive Regulatory Domain I-Binding Factor 1Programmed Cell Death 1 ReceptorGlutathione S-Transferase piGSTP1 protein, humanPDCD1 protein, humanPositive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanProgrammed Cell Death 1 ReceptorReactive Oxygen SpeciesReceptors, Chimeric AntigenBLIMP1CAR-T cell exhaustionGSTP1oxidative stressreactive oxygen species

Identifiers

PMID41080608
PMCPMC12511145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.