Evidence map›Paper›PMID 41080563›Full record

ArticleFrontiers in immunology2025

Gut commensal bacteria-derived polysaccharide sub-micron particles induce antigen-specific, tolerogenic responses.

Rian Harriman, Allen B Tu, Zhenyu Wang, Nicolas Radoc, Hamilton Kakwere, Jamal S Lewis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rian HarrimanDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
Allen B TuDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
Zhenyu WangJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Nicolas RadocDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
Hamilton KakwereDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
Jamal S LewisDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.

Funding

Particulate-based in vivo modulation for immunotherapy of Rheumatoid ArthritisR01AI139399 · NIAID · UNIVERSITY OF FLORIDA · PI LEWIS, JAMAL S · 2019 to 2023
$1.9M
SUGAR-COATING HYPOALLERGENS - A NOVEL APPROACH FOR SHELLFISH ALLLERGY IMMUNOTHERAPYR03AI138191 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEWIS, JAMAL S · 2019 to 2020
$151k
NIAID NIH HHS R01 AI139399NIAID NIH HHS R03 AI138191
6 · The paper itself

Abstract

Roughly 10.8% (>26 million) Americans suffer from food allergies (FA) which, in severe cases, can be life threatening. Oral immunotherapy (OIT) offers a promising allergen-specific approach in the management of FA. However, due to risk of anaphylactic shock, there are significant concerns regarding its safety and must be carried out in the hospital under careful supervision by clinicians. These concerns may be addressed through delivery of the allergen in engineered nanoparticulate packages which may additionally improve therapeutic efficacy. Polysaccharide A (PSA), a commensal-derived molecule produced by the gut-symbiont

Indexed as

Desensitization, ImmunologicFood HypersensitivityPolysaccharides, BacterialAllergensAnimalsAntigen PresentationBacteroides fragilisCD4-Positive T-LymphocytesCells, CulturedDendritic CellsFemaleGastrointestinal MicrobiomeImmune ToleranceImmunotherapyMaleMiceAllergensPolysaccharides, Bacterialdendritic cellsimmunomodulatorypolysaccharide aregulatorysub-micron particlesT cells

Identifiers

PMID41080563
PMCPMC12507582

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.