ArticleFrontiers in immunology2025
Protein phosphorylation regulation of key genes in oral squamous cell carcinoma and their role in the immune microenvironment.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the head and neck region, with a complex molecular mechanism that has not yet been fully elucidated. This study aims to identify key genes closely associated with the development and progression of OSCC through integrative multi-omics data analysis and to explore the potential roles of these genes in protein phosphorylation regulation and the immune microenvironment, providing new insights for precision diagnosis and treatment. Methods: The study integrated data from National Center for Biotechnology Information (NCBI) and National Institutes of Health (NIH) sources, combining differential expression gene analysis and co-expression network construction to identify candidate genes significantly associated with phosphorylation status. Key genes were further screened, and molecular subtyping of samples was performed based on gene expression patterns. Additionally, the association between key genes and immune microenvironment characteristics was evaluated, and Mendelian randomization (MR) was employed to investigate the impact of genetic variants on disease risk. Results: The analysis revealed multiple significantly differentially expressed genes, primarily enriched in pathways related to cell cycle regulation, signal transduction, and metabolism. Five key genes-BMP2, FN1, INHBA, MMP9, and THY1-were ultimately identified. These genes exhibited subtype-specific expression patterns across different molecular subtypes and were closely associated with immune cell infiltration levels. Furthermore, functional validation demonstrated that FN1 was significantly linked to OSCC occurrence at the genetic level. Conclusion: This study identified key genes and molecular subtypes associated with OSCC, highlighting their potential links to protein phosphorylation and the immune microenvironment. Among these, FN1 may serve as a potential risk gene and a candidate biomarker, providing novel insights into the molecular mechanisms of OSCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.