Evidence map›Paper›PMID 41080522›Full record

ArticleDigital discovery2025

Discovery of hybrid chemical synthesis pathways with DORAnet.

Quan Zhang, William W Sprague, Shivani S Kozarekar, Stefan C Pate, Taylor Uekert, Linda J Broadbelt

Abstract read
In one paragraph

Article in Digital discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Quan ZhangDepartment of Chemical and Biological Engineering, Northwestern University 2145 Sheridan Road Evanston Illinois 60208 USA broadbelt@northwestern.edu.ORCID https://orcid.org/0000-0002-9094-5686
William W SpragueDepartment of Chemical and Biological Engineering, Northwestern University 2145 Sheridan Road Evanston Illinois 60208 USA broadbelt@northwestern.edu.
Shivani S KozarekarDepartment of Chemical and Biological Engineering, Northwestern University 2145 Sheridan Road Evanston Illinois 60208 USA broadbelt@northwestern.edu.
Stefan C PateDepartment of Chemical and Biological Engineering, Northwestern University 2145 Sheridan Road Evanston Illinois 60208 USA broadbelt@northwestern.edu.
Taylor UekertStrategic Energy Analysis Center, National Renewable Energy Laboratory 15013 Denver West Parkway Golden Colorado 80401 USA.ORCID https://orcid.org/0000-0001-7645-9166
Linda J BroadbeltDepartment of Chemical and Biological Engineering, Northwestern University 2145 Sheridan Road Evanston Illinois 60208 USA broadbelt@northwestern.edu.ORCID https://orcid.org/0000-0003-4253-592X

Funding

Developing Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8M
Biotechnology Predoctoral Training ProgramT32GM153505 · NIGMS · NORTHWESTERN UNIVERSITY · PI Joshua Nathaniel Leonard · 2024 to 2026
$1.6M
NIGMS NIH HHS T32 GM008449NIGMS NIH HHS T32 GM153505
6 · The paper itself

Abstract

Developing efficient tools for discovering novel synthesis pathways is essential to advance chemical production methods that maximize the use of resources and energy. We introduce DORAnet (Designing Optimal Reaction Avenues Network Enumeration Tool), an open-source computational framework that addresses key limitations in current computer-aided synthesis planning (CASP) tools. DORAnet integrates both chemical/chemocatalytic (

Identifiers

PMID41080522
PMCPMC12512011

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.