ArticleCurrent developments in nutrition2025
Targeted Urinary Profiling as a Biomarker of Dietary Flavonoid Intake from Fruits and Vegetables and its Relationship to the Timing of Dietary Assessment.
Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03489213 (NExT), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NExT (Nutrition and Exercise Cancer Survivor Trial)
Who cites it
2 citing papers in PubMed.
- A Narrative Review of Candidate Biomarkers of Total Fruit and Vegetable Intake.Nutrition bulletin · 2026Review
- Dietary flavonoid intake is linked to reduced all-cause mortality: Findings from the National Health and Nutrition Examination Survey (NHANES).Pakistan journal of medical sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dietary intake of flavonoids, a class of plant (poly)phenols, is hypothesized to mediate a variety of beneficial health outcomes linked to fruits and vegetables (FV) intake. Absorbed flavonoids are metabolized and excreted in urine and may serve as biomarkers of FV intake and host metabolism, but defining the relationship of urinary biomarkers to the specific time of intake is unclear. Objectives: To characterize a targeted panel of 6 urinary flavonoids and determine the relationship to estimated dietary flavonoid intake over time in adults. Methods: Dietary flavonoid intake was estimated from both a 30-d food frequency questionnaire and 3-d diet records using the Phenol-Explorer database in 17 adults. Twenty-four-hour urine was collected, and a targeted panel of 6 urinary flavonoids (quercetin, phloretin, naringenin, hesperetin, kaempferol, and isorhamnetin) was quantified using high-pressure liquid chromatography-diode array detection (DAD). Results: Compared to estimated intakes from a 1 d or 3 d diet record, total urinary flavonoids were most strongly associated with total FV (excluding potatoes) (r Conclusions: Targeted flavonoid concentrations in a 24-h urine collection may serve as a biomarker for estimating dietary exposures over 2 d prior to completion of the urine collection, but not more distant dietary exposures.This trial was registered at clinicaltrials.gov as NCT03489213.
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Registered trials
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