Evidence map›Paper›PMID 41080460›Full record

ReviewFrontiers in cellular neuroscience2025

The role of small GTPases in Alzheimer's disease tau pathologies.

Peter Hoegy, Yan-Hua Chen, Qun Lu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Peter HoegyDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, United States.
Yan-Hua ChenDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, United States.
Qun LuDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, United States.

Funding

Homeostatic Reset as a New Therapeutic Paradigm for Slow Progression DiseasesR01GM146257 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LU, QUN · 2021 to 2025
$3.4M
NIGMS NIH HHS R01 GM146257
6 · The paper itself

Abstract

Microtubule-associated protein (MAP) tau stabilizes neuronal microtubules in axonal transport and contributes to healthy synapses. In Alzheimer's disease (AD), tau proteins become hyperphosphorylated, reduce microtubule binding, and aggregate into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs). Although the steps of this dysregulation of tau are well established, the mechanisms by which each step is regulated remain incompletely understood. Misfolded protein aggregates, such as amyloid

Indexed as

aggregationAlzheimer’s diseaseclearancehyperphosphorylationmicrotubule-associated protein tauneurofibrillary tanglespropagationsmall GTPases

Identifiers

PMID41080460
PMCPMC12507922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.