Evidence map›Paper›PMID 41080413›Full record

ReviewFrontiers in molecular neuroscience2025

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies.

Guolong Deng, Dayuan Liu, Yunxiang Zhong, Muyao Wang, Baoshou Su, Hongli Jiang, Yihao Zhai, Hao Peng, Caicai Zhang, Jigao Feng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guolong Deng *Department of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Dayuan Liu *Department of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Yunxiang Zhong *Department of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Muyao WangKey Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province & Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Basic Medical Sciences, Hainan Medical University, Haikou, China.
Baoshou SuDepartment of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Hongli JiangDepartment of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Yihao ZhaiDepartment of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Hao PengDepartment of Neurosurgery, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
Caicai ZhangKey Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province & Key Laboratory of Tropical Translational Medicine of Ministry of Education, College of Basic Medical Sciences, Hainan Medical University, Haikou, China.
Jigao FengDepartment of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy, a prevalent neurological disorder affecting millions globally, manifests as recurrent synchronous neuronal discharges that disrupt normal cerebral function. Emerging evidence characterizes this condition as a network-level hyperexcitability disorder driven by aberrant neuroelectrical synchronization. At the molecular level, intracellular calcium (Ca

Indexed as

epilepsytherapeutic targetsTRPCTRPMTRPV

Identifiers

PMID41080413
PMCPMC12507774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.