ArticleThe journal of allergy and clinical immunology. Global2025
Clinical and pathophysiological roles of lower lobe-dominant mucus plugs on computed tomography in patients with asthma with and without bronchiectasis.
Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- InhaledRespirology case reports · 2026Article
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28 authors.
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Abstract
Background: Despite the clinical relevance of mucus plugging, the role of spatial distribution of mucus plugs remains unclear in patients with asthma. Objective: We sought to examine whether greater lower lobe mucus plug dominance is associated with more clinical and pathophysiological impairments in 2 cohorts, including patients with and without bronchiectasis. Methods: Patients with asthma without and with clinical diagnosis of bronchiectasis underwent chest computed tomography at Kyoto University Hospital (Kyoto cohort) and Japanese multicenters (bronchiectasis and asthma [BEXAS] cohort), respectively. Mucus plugs in airways were visually scored on computed tomography, and the difference in mucus plug score between lower and upper-middle lobes (Δ mucus plug score) was calculated. Results: Among 176 (Kyoto) and 42 (BEXAS) enrolled patients, 82 and 33 exhibited mucus plug scores greater than or equal to 1, respectively. Higher Δ mucus plug score was associated with lower percentage of the predicted FEV Conclusions: Lower lobe-dominant mucus plugs were associated with lower lung function and exacerbations in patients with asthma, irrespective of comorbid bronchiectasis. The spatial distribution of mucus plugs additionally to whole-lung mucus plug score may help to understand clinical roles of mucus plugging in asthma.
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