ArticleCureus2025
Atypical Calcitriol-Mediated Hypercalcemia in Late Life: A Hypothesis-Generating Case.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Calcitriol-mediated hypercalcemia is most commonly associated with granulomatous disease or lymphoma and rarely occurs without an identifiable cause. We present the case of a 96-year-old woman who developed severe symptomatic hypercalcemia with elevated 1,25-dihydroxyvitamin D (calcitriol), low 25-hydroxyvitamin D (calcidiol), suppressed parathyroid hormone, and no evidence of malignancy, granulomatous disease, endocrine dysfunction, or vitamin D intoxication. She improved with intravenous fluids, calcitonin, and corticosteroids. We hypothesize that age-related impairment of the fibroblast growth factor 23-Klotho regulatory axis contributes to the dysregulation of calcitriol synthesis. This case highlights diagnostic challenges in elderly patients with hypercalcemia and raises the possibility of age-related mineral metabolism dysregulation as an underrecognized contributor to idiopathic calcitriol-induced hypercalcemia.
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