ArticleCureus2025
Hemoglobin C Disease With Splenomegaly and With Factor II Mutation Gene Thrombophilia: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Hemoglobin C (Hb C) disease is caused by a mutation that leads to reduced hemoglobin solubility, crystallization, and chronic hemolysis. We report on a patient with a homozygous Hb C disease, persistent fetal hemoglobin, and a heterozygous factor II mutation. This case illustrates the complex interaction between hemoglobinopathies and thrombophilia disorders, where the coexistence of Hb C disease and a factor II mutation significantly heightens the risk of thrombosis. Its geographic prevalence in the Caribbean, particularly Puerto Rico, reflects historical migration patterns and underscores the need for early detection and multidisciplinary care.
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