ReviewCureus2025
Intraoperative Cortico-Cortical Evoked Potential Monitoring for Tumor Resection in Eloquent Regions: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preserving neurological function during brain tumor surgery near the eloquent cortex is a major challenge. Cortico-cortical evoked potentials (CCEPs) have emerged as a promising modality for intraoperative mapping of functional connectivity, especially in areas responsible for language, movement, and sensory integration. Unlike traditional motor or sensory evoked potentials, CCEPs allow assessment of bidirectional cortico-cortical pathways and have shown utility in epilepsy surgery. Their integration into tumor resections near eloquent areas remains a developing frontier. This systematic review aimed to evaluate the clinical utility, methodological consistency, and limitations of CCEP monitoring during brain tumor surgery involving eloquent regions. The systematic search of the literature occurred in PubMed, Scopus, Web of Science, and Google Scholar, with the search period between 2015 and 2024. Eight articles were deemed eligible for inclusion, presenting original data on the use of CCEP intraoperatively or more antecedently in surgical settings involving the eloquent cortex. The extraction was based on the demographic information of the patient, stimulation parameters, signal processing, and clinical response. The risk of bias was evaluated through ROBINS-I (Risk of Bias in Non-randomized Studies of Interventions). CCEPs were associated with improved mapping accuracy in six of eight studies and enabled enhanced visualization of cortico-cortical connectivity. Studies also highlighted variability in stimulation protocols and the influence of signal preprocessing. Only three studies showed a low overall risk of bias, reflecting heterogeneity in design and population. CCEP monitoring is a promising tool for functional mapping during tumor resection in the eloquent cortex. However, methodological inconsistencies and limited tumor-specific data highlight the need for standardized protocols and larger, prospective studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.