ArticleCureus2025
Impact of New Diffusion-Weighted MRI Lesions Following Carotid Artery Stenting on Long-Term Stroke Recurrence.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective Carotid artery stenting (CAS) has become an established alternative to carotid endarterectomy (CEA). However, new ischemic lesions, detected by diffusion-weighted imaging (DWI), are frequently observed following the procedure, and their prognostic significance remains controversial. This study aimed to evaluate the impact of new DWI lesions following CAS on long-term stroke recurrence in patients who underwent CAS for carotid artery stenosis. Methods This retrospective cohort study analyzed 46 consecutive patients who underwent CAS for symptomatic carotid stenosis between January 2008 and December 2015. All participants had a DWI performed before and within 24 hours after the procedure. Patients were stratified into DWI-positive (DWI+) and DWI-negative (DWI-) groups based on the presence of new ischemic lesions. The primary endpoint was stroke or transient ischemic attack (TIA) recurrence during long-term follow-up. Statistical analysis included the Mann-Whitney U test for continuous variables, the Chi-square test for categorical variables, and Kaplan-Meier survival analysis for time-to-event outcomes. Results New DWI lesions were identified in 20 of 46 patients (43.5%) following CAS. Of the 46 patients, eight (17.4%) were lost to follow-up; thus, 38 were analyzed (16 DWI+ and 22 DWI-). During a mean follow-up period of 36.5 months (range, 12-60 months), stroke recurrence occurred in 2 of 16 patients (12.5%) in the DWI+ group, while no stroke recurrence was observed in the 22 patients of the DWI- group (p = 0.170). No significant difference was found between groups regarding myocardial infarction development (DWI+: 2/16 (12.5%) vs. DWI-: 3/22 (13.6%), p = 1.000). Conclusion New DWI lesions following CAS may serve as a potential risk marker for long-term stroke recurrence, although statistical significance was not achieved in this cohort. These findings suggest that patients with new post-procedural DWI lesions may represent a higher-risk subgroup; however, this hypothesis requires validation in larger, adequately powered cohorts before guiding clinical practice. Validation studies in larger patient cohorts are needed to confirm these preliminary findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.