Evidence map›Paper›PMID 41080268›Full record

ArticleCureus2025

The Possible Unveiling of Myasthenia Gravis via Allergy Shots.

Ami Thakor Philipp, Lorraine Anderson

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ami Thakor PhilippAllergy and Immunology, University of California Los Angeles, Los Angeles, USA.
Lorraine AndersonAllergy and Immunology, University of California Los Angeles, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report discusses subcutaneous allergen immunotherapy (SCIT) for allergic rhinoconjunctivitis and explores whether myasthenia gravis symptoms developed in a patient due to subcutaneous allergen immunotherapy treatment. SCIT is known to induce immune tolerance through the generation of allergen-specific regulatory T and B cells, increased allergen-specific IgG4, and suppression of effector cell responses, resulting in sustained clinical benefit for allergic disease. Although SCIT is considered safe and is not associated with an increased risk of autoimmune disease in large population studies, rare case reports have raised concerns about its potential to trigger autoimmune conditions. The most common triggers for autoimmune diseases, including myasthenia gravis, remain unclear, but allergic diseases themselves may confer an increased risk. This case report highlights the need for further research into the immunological mechanisms and potential triggers of autoimmunity in the context of allergen immunotherapy.

Indexed as

allergic rhinoconjunctivitisallergy immunotherapyallergy shotsanaphylaxismyasthenia gravis

Identifiers

PMID41080268
PMCPMC12510673

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.