ArticleCureus2025
Clinical Outcomes of Intravenous Thrombolysis in Acute Ischemic Stroke: A Prospective Observational Study From Mumbai.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Development of a Clinical Prediction Model for Ultra-Early Mild Acute Ischemic Stroke with Negative CT Results.International journal of general medicine · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This prospective observational study was conducted to evaluate the clinical outcomes of intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) in patients with acute ischemic stroke at a tertiary care center in Mumbai, India. A total of 54 eligible patients received intravenous rt-PA within 4.5 hours of symptom onset. The primary outcome was neurological improvement assessed by the National Institutes of Health Stroke Scale (NIHSS). The mean door-to-needle time was 54.2±21.2 minutes, with 77.77% of patients receiving treatment within 60 minutes of hospital arrival. A significant reduction in NIHSS scores was observed from baseline (9.09±3.69) to day seven post-treatment (2.27±1.96), with a p-value of <0.001, indicating substantial neurological recovery. There were three deaths recorded during the study period. The findings underscore the effectiveness of timely rt-PA administration in improving neurological outcomes in acute ischemic stroke. Optimizing door-to-needle time through streamlined acute stroke protocols remains essential to enhance therapeutic success in resource-constrained healthcare settings.
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Registered trials
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