Evidence map›Paper›PMID 41080202›Full record

ArticleNeuro-oncology practice2025

Gross total resection is associated with improvement and prognosis even in von Hippel-Lindau disease-related hemangioblastomas: Nationwide registry in Japan.

Shunsaku Takayanagi, Fusao Ikawa, Hirokazu Takami, Nao Ichihara, Hirofumi Nakatomi, Yoshitaka Narita, Nobuhiro Mikuni, Masahiko Wanibuchi, Atsushi Natsume, Toshihiko Wakabayashi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shunsaku TakayanagiDepartment of Neuro-Oncology, International Medical Center, Saitama Medical University, Saitama, Japan.
Fusao IkawaDepartment of Neurosurgery, Shimane Prefectural Central Hospital, Shimane, Japan.ORCID https://orcid.org/0000-0003-4205-1490
Hirokazu TakamiDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Nao IchiharaDepartment of Medical Innovation, The University of Osaka, Osaka, Japan.
Hirofumi NakatomiDepartment of Neurosurgery, Kyorin University, Tokyo, Japan.
Yoshitaka NaritaDepartment of Neurosurgery and Neuro-oncology, National Cancer Center Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4303-6006
Nobuhiro MikuniDepartment of Neurosurgery, Sapporo Medical University, Hokkaido, Japan.
Masahiko WanibuchiDepartment of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Atsushi NatsumeInstitutes of Innovation for Future Society, Nagoya University, Aichi, Japan.
Toshihiko WakabayashiCenter for Advanced Medicine and Clinical Research, Nagoya University, Aichi, Japan.
Shota TanakaDepartment of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Nobuhito SaitoDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although hemangioblastomas (HBs) are biologically benign, their management is often complicated, particularly in the context of von Hippel-Lindau disease (VHL). Few studies have investigated treatment outcomes of both VHL-related sporadic HBs in detail. This study assessed the clinical characteristics and neurosurgical outcomes of VHL-related and sporadic HBs using data from the nationwide Brain Tumor Registry of Japan database. Methods: Patients with HB who underwent surgery between 2001 and 2008 were included. Clinical and radiological findings, including preoperative and postoperative Karnofsky Performance Status (KPS) scores, were evaluated. Factors associated with improved postoperative KPS were identified using univariate and multivariate analyses. Postoperative outcomes were evaluated using the Kaplan-Meier method. Results: A total of 443 patients (68 with VHL) were analyzed, with a median follow-up duration of 57 months, and gross total resection (GTR) was achieved in 81% of patients. Compared to sporadic HB, VHL-related HB was associated with perioperative complications ( Conclusions: The prognosis was worse for VHL-related HBs than for sporadic HBs; however, GTR was associated with improved OS, even in VHL-related HBs. Surgical resection is of the utmost importance in treating HB, regardless of the etiology.

Indexed as

Brain Tumor Registry of Japangross total resectionhemangioblastomavon Hippel–Lindau disease

Identifiers

PMID41080202
PMCPMC12508742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.