ArticleFrontiers in nutrition2025
Probiotic intervention improves cholestatic parameters in patients with drug-induced liver injury: a real-world retrospective study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The gut-lung axis and viral pneumonia: Unrevealing the gut microbiota.Pharmaceutical science advances · 2026Review
- [Gut microbiota-associated metabolites with drug-induced liver injury].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
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Authors and funding
7 authors.
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Abstract
Objective: This study aimed to investigate the impact of gut microbiota intervention on the therapeutic outcomes in patients with drug-induced liver injury (DILI). Methods: A total of 120 patients with DILI who were hospitalized at the Second Hospital of Lanzhou University from January 2023 to December 2024 were retrospectively enrolled. Patients were divided into an intervention group and a control group based on whether they received gut microbiota intervention therapy. Quantitative data were presented as median and interquartile range, and the Mann-Whitney U test was used for intergroup comparisons. Categorical variables were compared between groups using chi-square tests. Logistic regression analysis was used to identify factors associated with liver injury severity and to evaluate the effect of gut microbiota intervention. Results: After treatment, GGT, ALP, TBIL, DBIL and IBIL decreased significantly more in the intervention group than in the control group, and the differences were statistically significant ( Conclusion: Probiotic intervention significantly improved cholestasis-related parameters and reduced the severity of liver injury in patients with DILI. This real-world study provides novel clinical evidence supporting microbiota-targeted therapy as a promising adjunctive strategy, particularly for cholestasis-predominant DILI.
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