Introduction: Methods: LC-MS analysis was conducted to identify the main active ingredients in DH water extract. A zebrafish AS model was used to screen for the active ingredients with therapeutic effects. Network pharmacology was utilized to predict the mechanisms through which these active ingredients treat AS. Results: Six main active ingredients were identified, and three, namely dendrophenol, naringenin, and apigenin-G, were selected for further study. Network pharmacology analysis indicated that naringenin and apigenin-G may treat AS by lowering blood lipid levels, including total cholesterol, triglycerides, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL), while dendrophenol may improve low shear stress (LSS)-induced endothelial cell dysfunction. Zebrafish model studies showed that naringenin and apigenin-G significantly reduced cholesterol, triglycerides, LDL, and VLDL levels. In the LSS-induced endothelial cell dysfunction model, dendrophenol significantly increased nitric oxide (NO) activity and reduced reactive oxygen species (ROS) activity. Discussion: The findings suggest that DH may treat AS through the lipid-lowering effects of naringenin and apigenin-G, and by improving endothelial cell dysfunction via dendrophenol. Given that DH is a homology-of-medicine-and-food, it is suitable for preparation as a functional food aimed at preventing AS.