Trial reportDrug design, development and therapy2025
Effects of Sevoflurane Versus Propofol Total Intravenous Anaesthesia on Renal Function in Elderly Patients Undergoing Hip Fracture Surgery: A Randomised Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Dexmedetomidine May Reduce the Incidence of Acute Kidney Injury in Elderly Patients Undergoing Orthopedic Surgery: A Randomized, Double-Blind Clinical Trial.Drug design, development and therapy · 2026Trial
- Interpreting perioperative oliguria during sevoflurane anesthesia: excretory physiology, fluid responsiveness, and renal endpoints.Journal of anesthesia · 2026Review
- Acute kidney injury after propofol or sevoflurane anaesthesia for colorectal cancer surgery: a secondary analysis.Anaesthesia · 2026Article
- Effects of Sevofurane versus Propofol Total Intravenous Anaesthesia on Renal Function in Elderly Patients Undergoing Hip Fracture Surgery: A Randomised Controlled Trial [Response to Letter].Drug design, development and therapy · 2025Article
- Beyond Function: Did Anesthetic Choice Influence Subclinical Kidney Injury Rather Than Estimated Glomerular Filtration Rate? [Letter].Drug design, development and therapy · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The impact of propofol-based total intravenous anaesthesia (TIVA) versus sevoflurane anaesthesia on renal function remains uncertain. We investigated the effect of anaesthetic type (propofol or sevoflurane) on renal function in elderly patients undergoing hip fracture surgery. Patients and Methods: In this randomised controlled trial, 66 elderly patients scheduled for hip fracture surgery were randomly allocated to either propofol or sevoflurane maintenance anaesthesia. The primary outcome was estimated glomerular filtration rate (eGFR) 1 hour postoperatively. Results: The mean age was 70 yr and 53% were female. Compared with the sevoflurane group, the propofol group exhibited significantly higher eGFR levels at 1 hour postoperatively (mean [SD]: 89.4 [13.4] vs 80.1 [17.3] mL min Conclusion: Propofol-based TIVA was associated with higher eGFR at 1 hour postoperatively, along with increased urine output, greater urinary sodium excretion, and lower plasma renin levels during anaesthesia in elderly patients compared with sevoflurane anaesthesia. These findings warrant further investigation to determine their implications for long-term renal outcomes and intraoperative fluid management in this vulnerable population. Trial Registration: Chinese Clinical Trial Registry (ChiCTR2300070049).
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