Trial reportDrug design, development and therapy2025
Effect of Opioid-Free Anesthesia on the Quality of Early Recovery After Total Hip Arthroplasty in Elderly Patients (Aged 65-80 Years) as Assessed by the QoR-15 Score: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Topical Airway Lidocaine Spray Reduces the 95% Effective Dose of Sufentanil for Blunting Hemodynamic Response to Tracheal Intubation in Elderly Patients: A Biased-Coin Up-and-Down Sequential Allocation Trial.Drug design, development and therapy · 2026Trial
- Effects of spontaneous breathing anesthesia on postoperative cognitive dysfunction in elderly patients: a narrative review.Frontiers in surgery · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Opioid administration in elderly surgical patients is link to multiple adverse effects that may impede postoperative recovery. We aimed to compare the impact of opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia on postoperative recovery quality in elderly patients undergoing total hip arthroplasty (THA). Methods: We randomized 68 elderly patients undergoing primary total hip arthroplasty under general anesthesia into either an opioid-free anesthesia group (Group OFA) or conventional opioid-based group (Group C). The primary outcome was quality of recovery assessed by the Quality of Recovery-15 (QoR-15) scores at 24h postoperatively. Secondary outcomes included: QoR-15 scores at 72h postoperatively, perioperative hemodynamic parameters, extubation time and PACU duration, NRS pain scores, postoperative sufentanil consumption and adverse event incidence. Results: The QoR-15 scores statistically significant differed between the two groups at 24h postoperatively (112.2±5.0 vs 102.6±4.7, mean difference = 9.6,95% CI: 7.3-12.0, Conclusion: We concluded that OFA provided superior early recovery outcomes compared to conventional opioid-based anesthesia in elderly total hip arthroplasty patients, with improvements in pain, emotional state, and physical comfort domains.
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