Evidence map›Paper›PMID 41079998›Full record

ArticleFrontiers in aging neuroscience2025

Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention.

Xuehua Zhou, Huiqian Yu, Yiru Wang, Kaizheng Chen, Xia Shen

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In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuehua Zhou *Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Huiqian Yu *Department of Otorhinolaryngology, ENT Institute, Eye and ENT Hospital, Fudan University, Shanghai, China.
Yiru WangDepartment of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Kaizheng ChenDepartment of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Xia ShenDepartment of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hearing loss during early life has been linked to later cognitive decline, but the underlying neural mechanisms remain unclear. To investigate the cognitive impact of early hearing loss in humans, adults aged 18-40 years with severe childhood hearing loss were evaluated using standardized cognitive assessments. In parallel mouse studies, a mouse model of sensorineural hearing loss was established to assess memory function, hippocampal microglial activation, Tau phosphorylation, and synaptic integrity at 1 and 4 months post-insult. Mice were also exposed to environmental enrichment to test its therapeutic effects. Our data showed that individuals with early hearing loss had a significantly increased risk of cognitive impairment (OR = 1.010, 95% CI: 1.002-1.017,

Indexed as

cognitive functionearly-life hearing lossenriched environmentlong-term effectsneurodegeneration

Identifiers

PMID41079998
PMCPMC12507710

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.