SynthesisFrontiers in aging neuroscience2025
Effects of three aerobic exercise modalities (walking, running, and cycling) on circulating brain-derived neurotrophic factor in older adults: a systematic review and meta-analysis.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Effects of Exercise Interventions on Peripheral Brain-Derived Neurotrophic Factor: An Umbrella Meta-Analysis Across Clinical and Healthy Populations.Journal of clinical medicine · 2026Review
- The Emerging Role of N-Lactoyl-Phenylalanine (Lac-Phe) in Metabolic Regulation and Disease: From Exercise-Induced Metabolite to Therapeutic Candidate.Antioxidants (Basel, Switzerland) · 2026Article
- Physical activity and exercise in dementia: clinical relevance and emerging insights.Frontiers in dementia · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recent studies indicate that older adults (aged 55 years and above) represent a critical period for changes in circulating brain derived neurotrophic factor (BDNF) levels and cognitive function. Regular aerobic exercise (AE) has been recognized as a promising non-pharmacological strategy to influence neuroplasticity and cognitive function, primarily through the regulation of BDNF. However, inconsistent findings have been reported regarding the specific effects of three AE modalities-walking, running, and cycling-on circulating BDNF levels in older adults. This study aimed to systematically evaluate the effects of these AE modalities on BDNF levels in the elderly through a meta-analysis, and to further compare the relative effectiveness of various exercise protocols using network meta-analysis. Methods: A systematic search was conducted from database inception to June 10, 2025, in PubMed, Web of Science, Embase, the Cochrane Library, and Scopus. The methodological quality and risk of bias of the included studies were assessed using the Cochrane Risk of Bias 2 tool. Meta-analysis and network meta-analysis were conducted using Stata software (version 18, StataCorp LLC, United States). Results: A total of 17 studies involving 900 older participants were included. Meta-analysis indicated that three AE modalities significantly increased circulating BDNF levels (SMD = 0.62, 95% CI: 0.06 to 1.18, Conclusion: Walking, running, and cycling are effective for improving circulating BDNF levels in older adults; however, the magnitude of improvement depends on participants' health status and specific exercise prescription. Interventions involving walking at low to moderate intensity demonstrated favorable efficacy. This effect may be more favorable in healthy individuals and those with mild cognitive impairment. Future studies should further investigate the influence of total exercise volume on outcomes and adopt more rigorous and standardized protocols to facilitate the development of standardized exercise strategies, thereby improving comparability and reducing heterogeneity in future analyses. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, Identifier CRD420251068909.
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