Evidence map›Paper›PMID 41079946›Full record

ReviewGut microbiome (Cambridge, England)2025

The gut microbiome and child and adolescent depression and anxiety: a systematic review and meta-analysis with youth consultation.

Susan C Campisi, Flora Zhang, Minjoo Seo, Jessica Muha, Anett Schumacher, Isabella De Luca, Glyneva Bradley-Ridout, Kaitlyn Merriman, John Parkinson, Daphne J Korczak

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut microbiome (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Susan C CampisiNutrition and Dietetics Program, Clinical Public Health Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-1072-9228
Flora ZhangNutrition and Dietetics Program, Clinical Public Health Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Minjoo SeoNutrition and Dietetics Program, Clinical Public Health Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Jessica MuhaNeuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-5317-1482
Anett SchumacherNeuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Isabella De LucaNutrition and Dietetics Program, Clinical Public Health Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Glyneva Bradley-RidoutGerstein Science Information Centre, University of Toronto, Toronto, ON, Canada.
Kaitlyn MerrimanGerstein Science Information Centre, University of Toronto, Toronto, ON, Canada.
John ParkinsonProgram in Molecular Medicine, Hospital for Sick Children, Toronto, ON, Canada.
Daphne J KorczakNeuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-0061-7495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decreased gut microbial diversity is associated with greater depression symptoms in adults. Findings on the relationship between the gut microbiome and depression or anxiety in children and adolescents are mixed, and evidence syntheses are needed. Seven databases were searched for peer-reviewed studies on the gut microbiome and internalizing symptoms, depression, or anxiety, in children and adolescents (<19 years). Random-effects meta-analyses of alpha diversity indices were performed. Youth advisors validated the research findings' relevance to their experiences and contributed to dissemination planning. Eight studies were included, representing 2,865 participants (mean age = 11.4 years, SD = 4.3). Study designs were cross-sectional (

Indexed as

adolescentsanxietydepressionmicrobiomereview

Identifiers

PMID41079946
PMCPMC12509154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.