Evidence map›Paper›PMID 41079933›Full record

ArticleInternational journal of biological sciences2025

Remodeling the Tumor Immune Environment in Breast Cancer via Bortezomib-based Combination Therapy.

Shaojuan Huang, Qiang Chen

Abstract readComment
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shaojuan HuangDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
Qiang ChenDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While proteasome inhibitors have revolutionized the treatment of hematologic malignancies and significantly improved patient survival, their efficacy in solid tumors remains limited. The recent work by Tang and colleagues demonstrates a novel combination strategy to overcome this limitation. Their study reveals that bortezomib, combined with either tetrathiomolybdate or AMD3100, synergistically kills breast cancer by downregulating expression of the proteasome subunit PSMB5. Crucially, the

Indexed as

Antineoplastic AgentsBoronic AcidsBreast NeoplasmsPyrazinesAnimalsBortezomibFemaleHumansMiceProteasome InhibitorsTumor MicroenvironmentAntineoplastic AgentsBoronic AcidsBortezomibProteasome InhibitorsPyrazinesAMD3100BortezomibDNA damagePSMB5TMTumor immune microenvironment

Identifiers

PMID41079933
PMCPMC12509888

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.